IL6 and cancer: As part of systemic inflammatory response to the tumor or from the tumor itself, proinflammatory cytokines including interleukin-1, IL-6, and necrosis factor ɑ are released, which may modulate albumin synthesis by hepatocytes [31, 32], these cytokines are crucial for malignant transformation, neoangiogenesis and cancer progression [31], thus nutritional status could serve as a good indicator of prognosis for cancer.