After 28 days of follow-up, we also found that the statistical differences were distinct in COPD (P = 0.006), DM (P = 0.005) tumor (P = 0.005), MBP (P < 0.001), heart rate (P = 0.013), Lac (P < 0.001), PCT (P < 0.001), PaO2/FiO2 (P < 0.001), CRP (P < 0.001), qSOFA score (P < 0.001), SOFA score (P < 0.001) and CURB-65 score (P < 0.001) between survivor (n = 443) and non-survivor (n = 299) groups (Table 1). The gene discussed is MBP; the disease is chronic obstructive pulmonary disease.