COX5A and brain ischemia: Moreover, the investigation was expanded in the ischemic-reperfusion model to further explore the effects of mitochondrial protein synthesis and COX activity, and the results showed that the degree of COX activity was also decreased to 90.3%, 80.3%, 81.9% and 83% of the control values at 15 min after cerebral ischemia and 1, 3, 24 h after reperfusion, respectively [21].