The diagnosis of AIP and accompanying OOI can be made according to the international consensus diagnostic criteria (ICDC)/Honolulu criteria12 or a modification13 of the original M-ANNHEIM criteria.14 IgG4 is useful but not an ideal biomarker for diagnosis of AIP type 1.15 Several other serum markers for AIP have been determined, including autoantibodies against lactoferrin, carbonic anhydrase II, the serine protease inhibitor kazal type 1 gene (SPINK1), ubiquitin, trypsinogens and N-glykan.16, –18 However, none of these are globally available for routine clinical testing. The gene discussed is SPINK1; the disease is autoimmune pancreatitis.