Spearman correlation analysis showed that plasma PCSK9 levels in patients with PNS had positive linear correlations with TC (r = 0.246, p = 0.008), LDL-C (r = 0.183, p = 0.049), and HDL-C (r = 0.186, p = 0.047), whereas there was no linear correlation with VLDL-C (r = 0.008, p = 0.930) and TG (r = 0.070, p = 0.457) (Figure 2). This evidence concerns the gene PCSK9 and paraneoplastic neurologic syndrome.