Similar to the ACTB mutations in DLBCL, a part of the ACTG1 mutations can affect a polymer contact, especially the ones near the D-loop (I64N, R62G, R62C, L65M) or in the Pro-rich region (L110V, P112S) (Figure 4b, Table 4). The gene discussed is ACTG1; the disease is diffuse large B-cell lymphoma.