Mutations in actins have previously not been mapped across different cancers or within one cancer (sub)type, however, mutations in cytoplasmic actins have been linked to different developmental diseases such as deafness-dystonia [36], progressive deafness [36,37,38,39], intellectual disability due to haploinsufficiency [7], Becker’s nevus syndrome due to low-grade mosaic postzygotic ACTB hotspot mutations [40], Baraitser-Winter cerebrofrontofacial syndrome (BWCFF) due to mutations in exons 2–4 [9,41] and ACTB-associated thrombocytopenia (ACTB-AST) due to mutations in exon 5 and 6 [42]. Here, ACTB is linked to Thrombocytopenia.