Also the eight ACTG1 mutations (T89I, K118N, K118M, E241K, P264L, T278I, P332A, V370A) involved in progressive hearing loss in autosomal dominant isolated neurosensory deafness type DFNA lead to specific changes in polymerization and F-actin severing by the actin-binding protein cofilin [39,45]. The gene discussed is ACTG1; the disease is hearing loss disorder.