ACTB and cancer: Inspecting the location of the somatic mutations across all cancers (except lymphoid cancers) in the primary structure of both cytoplasmic actin proteins (with protein symbol ACTB and ACTG1) using the lollipop representations of cBioPortal reveals that some mutations are found in more than one patient and that these are spread over the entire sequence with a potential hotspot for residues G158 and E334 in ACTB (Figure S3a,b).