We further determined the TLL1 gene SNP rs17047200, which was shown to be related to the development of hepatocellular carcinoma (HCC) in HCV-eradicated patients [23,24], since the combination of PNPLA3 and TLL1 SNPs was recently suggested to be associated with disease progression in Japanese NAFLD patients [25]. Here, PNPLA3 is linked to metabolic dysfunction-associated steatotic liver disease.