As described above, normalization of the VEGF-suppressed tumor microenvironment with molecular targeted agents against VEGF leads to the efficient attack on tumors by activated T cells [5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,27] (Figure 2 and Figure 4). This evidence concerns the gene VEGFA and neoplasm.