In a retrospective review of urban adult asthma patients, total serum IgE was highest in the 53 patients (17.3%) with fungal sensitization (median, 825 IU/mL vs. 42 non-atopic (n = 137, 44%) vs. 203 other allergen sensitized (n = 117, 38.1%), p < 0.001). This evidence concerns the gene IGHE and asthma.