CD163 expression alone is also a potential biomarker for diagnosis of glioma patients (AUC = 0.7565, Appendix Figure A2C ), whereas neither CD68 nor iNOS expression exhibits the diagnostic accuracy (CD68, AUC = 0.5851; iNOS, AUC = 0.6013) (Appendix Figure A2A,B). This evidence concerns the gene NOS2 and central nervous system cancer.