Most non-neoplastic urothelial epithelial cells or noninvasive urothelial carcinoma cells showed no expression of PD-L1, while HER2 and IDO were generally expressed with mild to moderate intensity in a large majority of reactive urothelial cells or noninvasive intraepithelial urothelial carcinoma cells, while there was no expression of IDO in normal urothelial epithelia. The gene discussed is CD274; the disease is urothelial carcinoma.