Confocal microscopy imaging on the CD44-negative neuroblastoma and the CD44-positive prostate cancer cells upon treatment (90 min of incubation time) with bare and HA-capped AuNPs highlighted some receptor-dependent and MW-dependent features in the cellular uptake of the hybrid HA-capped systems compared to the positive controls of bare NPs and HA (both low- and high-MW) (Figure 8, Figure 9, Figure 10 and Figure 11). This evidence concerns the gene CD44 and prostate cancer.