Cellular experiments were performed to test their interactions with human model cell lines, one that does not-express CD44, i.e., CD44-negative neuroblastoma tumor cells, SH-SY5Y [64] and two CD44-positive cell lines, which express the CD44 receptor on their surface membrane, namely prostate cancer, PC-3 [65] and HUVEC [45]. The gene discussed is CD44; the disease is neoplasm.