As listed in Table 1, they regulate the expression of gene/protein targets associated to cellular pathways that are deeply involved in MM pathogenesis, i.e., IL-6R/STAT-3, phosphoinositide 3-kinases (PI3K), mitogen-activated protein kinase (MAPK), p53, B-cell lymphoma-2 (Bcl-2), Cyclin D1, Notch, and vascular endothelial growth factor (VEGF). The gene discussed is VEGFA; the disease is Miyoshi myopathy.