An interesting point in this murine model was the differential expression of DNMT gene, as fibrotic mouse kidneys showed an increased DNMT1 expression, but not DNMT3a or DNMT3b expression compared to control kidneys, suggesting a specific role of DNMT1 in RASAL1 methylation and kidney fibrosis progression [98]. This evidence concerns the gene DNMT1 and urogenital neoplasm.