ESR1 and neoplasm: Univariate and multivariate analyses of histologic grade, tumor size at primary diagnosis and nodal status at primary diagnosis revealed ESR1 variants as independent predictors of OS (univariate: p-value = 0.0094 HR = 9.2; multivariate: p-value = 0.038 HR = 18.68) and survival time after the first diagnosis of metastasis (univariate: p-value = 0.0092 HR = 5.9; multivariate: p-value = 0.019 HR = 117.19).