Blockade of immunosuppressive signaling using monoclonal antibodies (mAbs) against PD-L1 or PD-1 induces the activation, differentiation and/or proliferation of tumor-infiltrating T cells via derepression of the PI3K-AKT signaling cascades while Myc is post-translationally stabilized via PI3K-AKT and RAS-MAPK signaling activation [29]. This evidence concerns the gene MYC and neoplasm.