SOCS2 and colitis: Figure 1D shows the average scores for wild-type and SOCS2−/− mice before, during induction and after recovery from colitis. Prior and during the acute phase of colitis, both mice groups showed no difference in the histological score of colitis. However, similar to the DAI, SOCS2−/− mice showed higher colitis severity compared to the wild type at the induction and recovery time point, with p-values < 0.01 and <0.001, respectively (Figure 1D). Figure 1E shows sections of the colon during the three phases of the colitis model.