The NF-κB family of transcription factors (RelA, c-Rel, RelB, NF-κB1 (p105/p50), and NF-κB2 (p100/p52)) comprises important mediators of the signaling pathways involved in the immune or inflammatory responses, cell proliferation, differentiation, and progression of multiple tumor types [13,14,15]. The gene discussed is NFKB1; the disease is neoplasm.