Inhalation of eCMVP by mice bearing lung melanoma metastases, induced by an intravenous (i.v.)injection of B16F10 cells, alters the lung microenvironment, with a significant increase in tumor-infiltrating neutrophils (TINs) and CD11b+Ly6G+-activated neutrophils as well as a reduction in CD11b−Ly6G+ quiescent neutrophils. Here, ITGAM is linked to neoplasm.