Unfortunately, on the contrary to what observed by the other authors about the sensitization of MDR tumor cells to established substrates of these efflux pumps, like vinblastine, etoposide, and mitoxantrone [95], we never have observed any reversal activity of P-gp-mediated resistance to doxorubicin by curcumin or its analogs in the MDR models described above [50]. The gene discussed is PGP; the disease is neoplasm.