In our study conducted on HCC cell lines (HA22T/VGH, Hep3B, and HepG2), we demonstrated that the silencing of MDA-9/Syntenin expression, obtained by a transient transfection with anti-MDA-9/Syntenin siRNA, downregulated NF-κB and the expression of some its targets while restoring the expression of RKIP, carrying out to strong reduction of MMP-2 dependent invasiveness [140]. The gene discussed is NFKB1; the disease is hepatocellular carcinoma.