ACTA1 and systemic sclerosis: Following this line of discovery, Manetti et al. [107] reported that dermal microvascular EC obtained from SSc patients (SSc-dMVECs) exhibited not only a spindle-shaped appearance but also an existence of low levels of CD31 and VE-cadherin with abundant MFB markers (α-SMA+ stress fibers, S100A4, and type 1 collagen).