TGFB1 and systemic sclerosis: In addition to TGF-β, Artlett et al. [122] have reported that IL-1 cytokine family including IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ, and IL-38 can also contribute to the skin inflammation and fibrosis in patients with SSc.