Compared to HFrEF, patients with HFpEF had less CAD, higher body mass index, less severe diastolic dysfunction (i.e. lower BNP and E/E’), more atrial fibrillation (AF) (31% versus 20%) and lower 6MWT distance (180m versus 210m; p = 0.038). This evidence concerns the gene NPPB and atrial fibrillation.