PANTHER analysis was used to identify the functional classification of these genes, and this indicated that variants were present in many genes within tumour-associated cellular pathways including: cell cycle regulation (cyclin E2 (Ccne2)); Ras signalling (Kirsten rat sarcoma viral oncogene homologue (Kras)); wnt signalling (wingless-type MMTV integration site family member 2B (Wnt2b)); interleukin signalling (Interleukin-3 receptor subunit alpha (Il3ra)) and apoptosis signalling (TNF receptor superfamily member 10a (Tnfrsf10a)) (Supplementary Table 3). This evidence concerns the gene TNFRSF10A and neoplasm.