Furthermore, the occurrence of adrenal tumours in male 129S6/SvEv Men1+/- mice was significantly higher than that in the male C57BL/6 Men1+/- mice (31.1% vs 11.6%, respectively, P < 0.05; Table 1), while the overall occurrence of adrenal tumours in female Men1+/- mice was similar at all ages between both strains (Table 1). This evidence concerns the gene MEN1 and adrenal gland neoplasm.