Thus, overall, more pituitary tumours developed in female C57BL/6 Men1+/- mice than in female 129S6/SvEv Men1+/- mice, while more adrenal tumours developed in male 129S6/SvEv Men1+/- than in male C57BL/6 Men1+/- mice and more ovarian tumours developed in 129S6/SvEv Men1+/- mice than in C57BL/6 Men1+/- mice (Table 1). This evidence concerns the gene MEN1 and adrenal gland neoplasm.