MKI67 and intraepithelial neoplasia: Although the immunoexpression of Ki-67 was slightly higher in DysOL than in Non-dysOL, the difference was not statistically significant, as found in previous studies.30 , 31 Furthermore, the same study showed that Ki-67 expression was progressively higher depending on the degree of epithelial dysplasia.32 Therefore, our findings reinforce that Ki-67 expression is a valuable predictive marker for oral leukoplakia progression, reinforcing the presence of mitosis in the upper half of the epithelium as an important criterion in the morphological analysis, as recommended by previous studies.6 , 33