Several serological biomarkers are included in the American College of Rheumatology (ACR)/EULAR classification criteria for RMDs (eg, ACPA and RF in RA [27], anti-dsDNA and anti-Sm in SLE [28], Scl70, anti-CENP and anti-RNA polymerase III in SSc [29], anti-Jo-1 in myositis [30] and anti-SSA/Ro in SS [31]). This evidence concerns the gene CALR and myositis disease.