To clarify the mechanisms underlying the effects of miR‐646 on NSCLC cell proliferation and invasion, we predicted putative targets of miR‐646 by bioinformatic analysis, and it revealed that miR‐646 could bind to the 3'‐UTRs of FGF2 and CCND2. This evidence concerns the gene CCND2 and non-small cell lung carcinoma.