The results elucidated that the suppressive effects of miR‐646 on cell proliferation and invasion were reversed by transfection of both expression constructs (Figure 6F‐H), suggesting that FGF2 and CCND2 were functionally important for the suppression of miR‐646 on NSCLC cell proliferation and invasion. The gene discussed is CCND2; the disease is non-small cell lung carcinoma.