PTPRD and Anxiety: These results indicate that hyperactive behavior during light‐off and light‐on periods in Laboras cages is highly similar among Ptprd−/−, Emx1‐Cre;Ptprdfl/fl, and Ptprd‐meA−/− mice, and that anxiety‐like behaviors are partly similar among Ptprd−/−, Emx1‐Cre;Ptprdfl/fl, and Ptprd‐meA−/− mice.