Ptprd−/− mice displayed mixed anxiety‐like behaviors, showing normal behavior in the open‐field center region, but moderately anxiolytic behavior in the elevated plus‐maze and anxiety‐like behavior in the light–dark apparatus; all of these behaviors were more closely mimicked by Emx1‐Cre;Ptprdfl/fl mice compared with Viaat‐Cre;Ptprdfl/fl and Camk2a‐Cre;Ptprdfl/fl mice (Fig EV4C–G). This evidence concerns the gene SLC32A1 and Anxiety.