In contrast, other tumor types benefit from high CREB expression, such as clear cell renal cell carcinoma (ccRCC) (HR 0.38, 95% CI 0.14–1.03, p < 0.001), lung adenocarcinoma (HR 0.76, 95% CI 0.55–1.03, p = 0.077), esophageal squamous cell carcinoma (HR 0.38, 95% CI 0.14–1.03, p = 0.05), and breast cancer (BC) (HR 0.56, 95% CI 0.41–0.79, p < 0.001). The gene discussed is CREB1; the disease is breast cancer.