After the intervention of IL-38, the expression of IL-1β, IL-6, TNF-α, IL-17, IL-13 decreased and IL-10 increased in the CLL group (P<0.05 vs CIA), while in the CLH group, the expression of IL-1β, IL-6, TNF-α, IL-17 and IL-13 was significantly decreased and the IL-10 was significantly increased (P<0.05 vs CLL&CIA). The gene discussed is IL1F10; the disease is B-cell chronic lymphocytic leukemia.