After IL-38 intervention, the expression of OPG in serum of CLL group was slightly increased, and the expression of RANKL and RANK was slightly decreased (P<0.05 vs CIA), which suggests that IL-38 can promote the up-regulation of OPG expression in serum of CIA rats and down-regulate the expression of RANKL and RANK. Here, TNFRSF11A is linked to B-cell chronic lymphocytic leukemia.