Besides antiseptic, skin whitening, anti-inflammatory andanti-tussive properties of arbutin, it might have the potential to be an anti-tumor andanti-oxidative agent which could be related to P53 regulation (8, 21).Tert-butyl hydroperoxide as a potent oxidative stress stimulator has been used to induceoxidative damage in vitro and in vivo (13). This evidence concerns the gene TP53 and neoplasm.