In normal colon tissues, the expression of ICAM-1 in intestinal mucosa lamina propria, monocytes andvascular endothelial cells is very low, and the affinityof its ligand LFA-1 also decreases accordingly (37).Consistent with previous reports in IBD patients (32)and DSS treated mice (38), we found that the proteinexpression of ICAM-1 was significantly increased inthe model group. The gene discussed is ICAM1; the disease is inflammatory bowel disease.