According to several recent studies, lots of anti‐osteoporosis drugs were derived from traditional Chinese medicine.24, 38, 39 Triptolide was derived from the traditional Chinese herb lei gong teng, which means thunder god vine.19 Triptolide was well known as a kind of anti‐cancer drugs,40 and recent study revealed that triptolide might have the effect to regulate bone metabolism.41, 42, 43, 44 Huang et al43 reported that triptolide could inhibit RANKL‐induced osteoclastogenesis and prevent osteolysis. Here, TNFSF11 is linked to osteoporosis.