TNFRSF11A and osteoporosis: However, it has been demonstrated by multiple researches that the imbalance between bone formation and bone resorption is the major cause.9 During the pathogenesis of osteoporosis, inflammation‐induced osteoclastogenesis overactivation after menopausal contributed most to the bone metabolism imbalance.10, 11 Thus, one of the important strategies to prevent and treat osteoporosis is to suppress inflammation.12, 13, 14 The origination of osteoclastogenesis is RANK/RANKL interaction.