Previous studies have reported that endocan expression is regulated by the proangiogenic factors VEGFA and VEGFC (Rennel et al., 2007; J. W. Shin, Huggenberger, & Detmar, 2008) and is directly correlated with tumor angiogenesis (L. Y. Chen, Liu, Wang, & Qin, 2010; Roudnicky et al., 2013). Here, VEGFA is linked to neoplasm.