SPTLC2 and schizophrenia: Previous studies have shown that levels of SM and Cer were reduced in postmortem brain and skin samples, respectively, from patients with schizophrenia.16,26 Furthermore, an altered expression level of the gene for SPT long chain base subunit 2 (SPTLC2), 1 of 3 different subunits of SPT, was observed in brain samples from patients with schizophrenia.27 However, the role of sphingolipids in schizophrenia has not been sufficiently addressed.