The expression levels of Sphingosine-1-Phosphate Lyase 1 (SGPL1) and Phospholipid Phosphatase 3 (PLPP3) showed a significantly higher (P = .006) and an elevated trend (P = .09), respectively, in the corpus callosum of patients with schizophrenia compared with controls (figure 2B). This evidence concerns the gene PLPP3 and schizophrenia.