In the multivariable analysis, a non-Euro Caucasian origin (aOR, 3.08, 95%CI [1.37–6.93]), previous delivery of a LGA infant (aOR, 3.21, 95%CI [1.31–7.87]), institution of treatment after 32 WG (aOR, 3.92, 95%CI [1.86–8.25]), and insulin therapy (aOR, 2.91, 95%CI [1.20–7.03]) were all associated with failure of GDM management (Table 6). The gene discussed is INS; the disease is gestational diabetes.