The antiphospholipid syndrome (APS) is characterized by clinical manifestations (venous or arterial thrombosis and/or recurrent pregnancy loss) occurring in patients with persistent antiphospholipid antibody positivity [either anticardiolipin antibody (aCL), lupus anticoagulant (LA, otherwise known as non-specific inhibitor), and/or anti-beta-2 glycoprotein-1 antibody (aβ2GP1), positive on ≥ 2 occasions ≥ 12 weeks apart] [1]. Here, ACLY is linked to autoimmune polyendocrinopathy.