Moreover, UBE2N encodes a protein that is a member of the E2 ubiquitin–conjugating enzyme family and helps to catalyze the synthesis of non-canonical “Lys-63”-linked polyubiquitin chains leading to transcriptional activation of genes involved in tumor proliferation and metastasis (Gallo et al., 2017; Vallabhaneni et al., 2017). The gene discussed is UBE2N; the disease is neoplasm.