KIT and mastocytosis: On the other hand, response to imatinib in terms of significant MC cytoreduction (i.e. ≥50%) in those patients who are not screened for the KIT mutation in the absence of imatinib-sensitive mutations involving other genes (e.g. PDGFR) is anecdotal (i.e. 3%) (Alvarez-Twose et al., 2017), which highlights the relevance of the study of the KIT mutational status before selecting potential candidates to imatinib therapy among patients with mastocytosis.