NPM1 and acute promyelocytic leukemia: For example, FTO, an m6A eraser, was highly expressed in AMLs with mixed-lineage leukemia (MLL) rearrangements, PML (promyelocytic leukemia)-RARA (retinoic acid receptor alpha) translocations, and/or FLT3 (FMS-like tyrosine kinase-3)-ITD (internal tandem duplication) or NPM1 (nucleophosmin 1) mutations88.