For instance, APA of short or long isoforms of CD47 mRNA affects the interaction with different protein complexes and thereby guides CD47 localization to either the plasma membrane (long isoform) or the endoplasmic reticulum (short isoform) in breast cancer, cervical cancer, ovarian carcinoma, leukemia, sarcoma, glioblastoma and neuroblastoma52. The gene discussed is CD47; the disease is sarcoma.