We investigated the inhibitory effect of five curcumin analogues on p300-HAT activity and found that GO-Y030 ((1E,4E)-1,5-bis[3,5-bis(methoxymethoxy)phenyl]-1,4-pentadiene-3-one) inhibits p300-HAT activity and the development of heart failure in mice much more strongly than does curcumin. The gene discussed is EP300; the disease is heart failure.