CD4 and Huntington disease: It is confirmed that Tregs are crucial to maintain immune cell homeostasis in numerous diseases.9 CD4+CD25+CD127− Tregs (Fig. 1f, upper panel) and CD4+CD8+CD25- DPT cells (Fig. 1f, lower panel) both have a high capacity to produce cytokines that act as immunosuppressive regulators of leukocyte trafficking.10,11 We therefore profiled their expression and found that the levels of functional molecules such as CXCR3, CD28, and TGF-β were obviously higher in the patient groups than in the HD group (Fig. 1f).