CFH and age-related macular degeneration: In summary, the A allele of C2-CFB-SKIV2L rs429608 was associated with visual improvement while the T allele of ARMS2 A69S and C allele of CFH rs1329428 were associated with the need for retreatment and a greater number of additional injections during the first 12 months of PRN aflibercept therapy among treatment naïve exudative AMD of Japanese descent.