NQO1 and obesity due to melanocortin 4 receptor deficiency: These findings are supported by a previous study demonstrating that cilostazol attenuates doxorubicin-induced HO-1 and NQO-1 expression in cardiac fibrosis20 and that NQO1 and eNOS are activated in obesity in response to reactive oxygen species (ROS) to protect against oxidative stress34.