These findings are supported by a previous study demonstrating that cilostazol attenuates doxorubicin-induced HO-1 and NQO-1 expression in cardiac fibrosis20 and that NQO1 and eNOS are activated in obesity in response to reactive oxygen species (ROS) to protect against oxidative stress34. Here, HMOX1 is linked to obesity due to melanocortin 4 receptor deficiency.