APP and Stroke: Thus suggesting that a marked degree of hypoperfusion-ischemia that may remain however below the T2-weighted MRI detectability and does not lead to strokes, may trigger APP misfolding and may explain the link between brain microstructural changes detected on diffusion tensor imaging (DTI) and likely hypoxic-ischemic hyperintensities in white matter, detected decades before the onset of symptomps and autosomal dominant AD cases66,67 as well as common late-onset sporadic cases and elderly people68.