Interestingly, SORL1 p.E270K and p.A528T clustering in the vacuolar protein sorting (VPS10) domain (Aa 124–757) have been found in 2/96 SVID patients homozygous for APOE ε3 allele and have been reported pathogenic and to segregate within AD families41. The gene discussed is APOE; the disease is Alzheimer disease.