CTSD and ischemia: By contrast, Plat, Ctsd and Klk6, displayed a specific time and region pattern of overexpression: Plat was overexpressed in prefrontal cortex and striatum 2 days post-ischemia and Ctsd and Klk6 in striatum and hippocampus 7 days post-surgery, both tissues characterized by the highest degree of tissue remodelling and overall differential expression (Table 6).