This is further supported by the fact that significant overexpression of Cd33, Ms4a6d and Apoe (> 1.5 fold change and adj p-value <0.05) markedly correlated with AD pathology in 2 mouse models of Alzheimer’s disease characterized by severe Aβ plaques and tau tangle deposition (HOTASTPM and TAU mice, 18 months of age)62. Here, CD33 is linked to early-onset autosomal dominant Alzheimer disease.