APP and ischemia: The predominant role of APP-Aβ degradation genes was further confirmed by RNA sequencing data in a mouse model of mainly subcortical ischemia, mimicking small vessel ischemic disease, where only genes belonging to the APP-Aβ degradation path (A2m, Plat, Ctsd, Ctsb and Klk6) were significantly overexpressed in hippocampus and striatum during acute and subacute hypoperfusion (Table 6).