Finally, among CST3 p.A25T homozygous carriers only 1/4 (25%) patients presented 3 moderate risk factors for SVID: hypertension, myocardial infarction and type 2 diabetes, 3/4 (75%) displayed hypertension and 1/4 (25%) did not present any risk factor for SVID (Table S3). This evidence concerns the gene CST3 and hypertensive disorder.