CWC22, the other upregulated hub genes in the LN(+) group, is a CWC22 spliceosome associated protein and has been suggested to be an unfavorable prognostic marker in renal and liver cancer (https://www.proteinatlas.org/ENSG00000163510-CWC22/pathology), although its function still needs to be investigated. The gene discussed is CWC22; the disease is liver cancer.