One notable example was a PIDS (cg00271210) in an enhancer region predicted to interact in 3D space with the promoter regions of two genes (i.e., RNASET2 and RPS6KA2), the expression levels of both of which were associated with ulcerative colitis (UC) and CD as reported in our previous study19 (Fig. 6). The gene discussed is RNASET2; the disease is ulcerative colitis.