Aberrant activation of Wnt/β-catenin signaling has been shown to play a pathogenic role in renal fibrosis in obstructive nephropathy2 and diabetic nephropathy.3 However, the role of low-density lipoprotein receptor-related protein 5 (LRP5), a co-receptor of Wnt/β-catenin signaling,4 has not been well characterized in these diseases. Here, LRP5 is linked to diabetic kidney disease.