A recent study reported that high LRP5 levels in patients were associated with faster progression of idiopathic pulmonary fibrosis (IPF) through activation of Wnt/β-catenin signaling,5 implicating an important role of LRP5 in Wnt/β-catenin signaling-related pulmonary fibrotic diseases. Here, LRP5 is linked to pulmonary fibrosis.