LRP5 and type 1 diabetes mellitus: Western blot analysis showed that renal LRP5 levels were significantly increased in 3-month-old Akita mice (type 1 diabetes) and 6-month-old db/db mice (type 2 diabetes) relative to their genetic background- and age-matched wild-type (WT) non-diabetic controls, accompanied by increased renal levels of collagen I and collagen III (Fig. 1a–d).