In contrast, while multiple mutations in FZR1, the gene encoding Cdh1, across several tumor types cluster in the degron region of the protein, the majority of these mutations (e.g., D140N, D144N, within the core degron) would seem likely to antagonize down-regulation of Cdh1 rather than promote it (www.cbioportal.org). This evidence concerns the gene FZR1 and neoplasm.