ccRCC patients with baseline serum PTX3 levels <165.0 pg/ml showed significantly higher 10-year rate of overall survival, as compared with ccRCC patients with serum PTX3 levels >165.0 pg/ml (73.7% vs. 48.4%, p=0.002; Figure 6). This evidence concerns the gene PTX3 and nonpapillary renal cell carcinoma.