To estimate the relative risk for cancer-specific survival (CSS) and progression-free survival in ccRCC patients showing serum PTX3 level above or below the operational cut-off, Cox regression analyses were performed using cancer-related death and recurrence as dependent variables, and T stage (T3-4 vs. T1-2), lymph node invasion (N+ vs N0), metastatic disease (M+ vs M0), Furhman grade (G1-2 vs. G3-4), tumor necrosis and size, and PTX3 serum levels as covariates (Table 2). This evidence concerns the gene PTX3 and metastatic neoplasm.