The factors affecting CD59 expression in this setting remain to be clarified, although the inflammatory milieu may represent the answer also for this event, since Bjorge et al. reported that two key pro-inflammatory cytokines, interleukin-1 (IL-1) and tumor necrosis factor alpha, induce the expression of CD59 in human colonic adenocarcinoma cells [47]. The gene discussed is CD59; the disease is colon adenocarcinoma.