Several reports analyzing PTX3 overexpressing cells have suggested that this long pentraxin may exert a pro-tumorigenic role by promoting tumor cell migration and invasion (cervical cancer, head and neck tumors) or proliferation (glioma), epithelial-to-mesenchymal transition (hepatocellular carcinoma) and macrophage chemotaxis [31–34]. This evidence concerns the gene PTX3 and neoplasm.