The analysis showed that PTX3 serum levels were significantly associated with ccRCC-specific survival (AUC:0.83, p<0.0001) and identified a cutoff value of 165.0 pg/mL with an 86% (95%CI: 73.3-94.2) specificity and a 70.7% (95%CI: 60.7-79.4) sensitivity. Here, PTX3 is linked to nonpapillary renal cell carcinoma.