Unexpectedly, however, GSDMD-independent secondary necrosis does not appear to be important in models of autoinflammatory diseases because Gsdmd deficiency rescues mice expressing mutant NLRP3 or Pyrin, linked to neonatal-onset multisystem inflammatory disease and familial Mediterranean fever (Xiao et al, 2018; Kanneganti et al, 2018a). The gene discussed is NLRP3; the disease is familial Mediterranean fever.