It remains to be determined how much GSDME is expressed by CL-26 cells, a murine colorectal carcinoma cell line, compared with macrophages (Tsuchiya et al, 2019), but overwhelming evidence suggest that at least in macrophages, GSDME expression or activity appear to be insufficient to induce GSDME-dependent cell death after caspase-3 activation (Lee et al, 2018; Sarhan et al, 2018; Vince et al, 2018; Chen et al, 2019). This evidence concerns the gene GSDME and colorectal carcinoma.